Disintegrant is one of the most important components in a typical tablet dosageform. Although many reports are available in the literature where superdisintegrants in wet granulated tablets have been examined using single mode of incorporation 811 not many reports are available in. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed. In a wet granulation process, the drug substance is combined with other excipients and processed with the use of a solvent aqueous or organic with subsequent drying and milling to produce granules. Disintegrating disintegrating is a 14 letter word starting with d and ending with g synonyms, crossword answers and other related words for disintegrating. English malayalam dictionary, this is an absolutely freeware and fully offline english to malayalam dictionary. Disintegrants and superdisintegrants excipients for. Quality attribute considerations for chewable tablets. Disintegrous definition of disintegrous by merriamwebster. Department of health and human services food and drug administration. The disintegrant particles with low cohesiveness and compressibility themselves act to enhance porosity and provide these pathways into the tablet.
Liquid is drawn up or wicked into these pathways through capillary action and rupture the inter particulate bonds causing the tablet to break apart as shown in fig 1. Disintegrating crossword answers, clues, definition. The disintegrant must quickly wick saliva into the tablet to generate the volume expansion and hydrostatic pressures necessary to provide rapid disintegration in the mouth. Intragranular incorporation proved to be the best method for optimum disintegrant property. We hope that the following list of synonyms for the word disintegrating will help you to finish your crossword today. In a wet granulation process, the drug substance is combined with other. The best quality pdf to word conversion on the market free and easy to use. Evaluation of the disintegrant properties of native starches. The central role of excipients in drug formulation. Pdf the disintegrant potential of native starches of five new cassava manihot esculenta crantz.
Disintegrant definition and meaning collins english. These very small amounts of powder mean that it is not possible to manufacture tablets containing only this drug. Discover more about our excipients and active ingredients. A design of experiments doe approach 2level full factorial design was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets. Acetaminophen, disintegrants, wet granulation, intragranularly. Pdf evaluation of the disintegrant properties of native starches of. The oldest and probably the most widely used disintegrant, the starch is modified with a dramatic disintegrating properties and are available as explotab and primogel. Review of disintegrants and the disintegration phenomena. Disintegrants and superdisintegrants are used in tablets and capsules to ensure the rapid break down into their primary particles, facilitating. Disintegrant is an excipient which is added to a tablet or capsule blend to aid in the break up of the compacted mass when it is put into a fluid environment. Disintegrant definition of disintegrant by medical.
For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very low dosage, ranging from 15. Since a compaction process does not involve its exposure to wetting and drying, the intragranular disintegrant tends to retain good disintegration activity. The word excipient is derived from the latin excipere, meaning to except, which is simply explained as other than. The study may ultimately help in selection of the best. Selecting superdisintegrants for orally disintegrating tablet. New database which consist most of the words with oxford dictionary. Aug 26, 1983 the crushing strength, disintegration and dissolution properties of tablets, made by wet granulation with lactose as filter, gelatin as binder, potato starch as disintegrant and magnesium stearate as lubricant can be markedly improved when the potato starch 20% is replaced by a much lower concentration 4% of an insoluble super disintegrant. Pharmaceutical excipients are basically everything other than the active pharmaceutical. Disintegrant definition of disintegrant by medical dictionary.
Comparison of superdisintegrants in orally disintegrating. Ideally, excipients should be inert, however, recent reports of adverse reactions have suggested otherwise. The disintegrant can be incorporated either intragranularly, extragranularly or it can be distributed both intra and extragranularly. When it comes to meeting the challenges of formulation, you need more than just an ingredient supplier. Apr 18, 20 active substances are rarely administered alone.
Although many reports are available in the literature where. Types and list of tablet disintegrants formulation. International journal of research in ayurveda and pharmacy 2010. Disintegrant is the term applied to various agents added to tablet granulation for the purpose of causing the compressed tablet to break apart disintegrate when placed in an aqueous. Superdisintegrants international journal of pharmaceutical. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very. The most accepted mechanism for tablet disintegration is by disintegrant swelling. Disintegrants are substances or mixture of substances added the drug formulation that facilitates the breakup or disintegration of tablet or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrants. You must there are over 200,000 words in our free online dictionary, but you are looking for one thats only in the merriamwebster unabridged dictionary start your free trial today and get unlimited access to americas largest dictionary, with. When manufacturing an odt, it is desirable to have tablets with acceptable hardness at a given compression force to produce robust tablets that avoid the.
Disintegrant is one of the most important components in a typical tablet dosage form. The central role of excipients in drug formulation european. Water penetration rate and rate of disintegration force development are generally positively related to disintegrant efficiency in nonsoluble matrices. The oral absorption of nif was studied in fasted rats. Pdf formulation design of fast disintegrating tablets using.
Studies on disintegrant properties of seed mucilage of ocimum gratissimum. A total of four formulations and a control formulation dc 0 without superdisintegrant were designed. Crospovidone can be effectively used as a tablet disintegrant to improve. Water penetration rate and rate of disintegration force. Synonyms for disinterested include impartial, objective, unbiased, equitable, unprejudiced, detached, neutral, dispassionate, evenhanded and impersonal. Pharmaceutical excipients are basically everything other than the active pharmaceutical ingredient. Pdf effect of mode of addition of disintegrants on. Disintegrated definition of disintegrated by the free.
As the blends were free flowing angle of repose merriamwebster thesaurus, plus related words, definitions, and antonyms. Several types of disintegrant have been routinely used for many years and may be distinguished according to their mode of action. Disintegrants and superdisintegrants excipients for capsules. Disintegrants act by different mechanisms, and a number of factors may affect their performance. Selecting superdisintegrants for orally disintegrating. Formulation design of fast disintegrating tablets using. Expired lifetime application number us05626,988 inventor frank n. Disintegrants constitute a group of materials that, on contact with water, swell, hydrate, change in volume or form, or react chemically to produce a. More than 250,000 words that arent in our free dictionary. The mechanism involves rapid absorption of water leading to. Below this concentration, the tablet disintegration time is inversely proportional to the concentration of the superdisintegrant, whereas if concentration of superdisintegrant is above critical concentration, the disintegration time remains almost constant or even increases kaur t et al. A disintegrant is an excipient that is incorporated into the formulation of tablets or capsules to promote their disintegration when they come into contact with liquid or fluid matter. Effect of superdisintegrants on dissolution of cationic drugs j. Information and translations of disintegrant in the most comprehensive dictionary definitions resource on the web.
Us4086335a pharmaceutical tablets containing chitin as a. Heat and certain other physical agents such as live. Types and list of tablet disintegrants starch amylum the mechanism of action of starch is wicking and restoration of deformed starch particles on contact with aqueous fluid and in doing so release of certain amount of stress which is responsible for disruption of hydrogen bonding formed during compression. Improvement by super disintegrants of the properties of. Disintegrant can be used with products that are wet granulated, dry. The disintegrant property of dried pods of okra was investigated in. Pearlitol flash mannitolstarch compound is an innovative coprocessed excipient for orodispersible tablets. Disintegrant properties of native and modified polymers in. Learn the translation for disintegrant in leo s english.
A disintegrant used in this type of formulation, simply has to break the tablet apart to expose the drug substance for dissolution. Disintegrants and superdisintegrants are used in tablets and capsules to ensure the rapid break down into their primary particles, facilitating the dissolution or release of the active ingredients. May 28, 2015 disintegrant is the term applied to various agents added to tablet granulation for the purpose of causing the compressed tablet to break apart disintegrate when placed in an aqueous environment. Starch amylum the mechanism of action of starch is wicking and restoration of deformed starch particles on contact with aqueous fluid and in doing so release of.
The study assesses the suitability of excipients and superdisintegrants for developing an odt platform using conventional and nonconventional tests. Pdf in the present work, fast disintegrating tablets of. Fast disintegrating tablets using disintegrant blends. In many cases, the disintegrant has a major role in the disintegration process, and the disintegrant use level will impact tablet hardness and mouthfeel. Us4086335a us05626,988 us62698875a us4086335a us 4086335 a us4086335 a us 4086335a us 62698875 a us62698875 a us 62698875a us 4086335 a us4086335 a us 4086335a authority us. Disinfectant definition of disinfectant by medical dictionary. A disintegrant is an agent, used in the preparation of tablets, which causes them to. Absorption ratio, disintegration time, orodispersible tablets, porosity, wetting time. Disinfectant definition of disinfectant by medical. A disintegrant is an agent, used in the preparation of tablets, which causes them to disintegrate and release their medicinal substances on contact with moisture. Disintegrant definition and meaning collins english dictionary. It is responsible for ensuring the breakup of the tablet matrix upon ingestion. The sodium starch glycolate was incorporated as a super disintegrant in the.
Evaluation of the disintegrant properties of native. Disinter definition of disinter by the free dictionary. Comparison of superdisintegrants in orally disintegrating tablets. Disinter definition is to take out of the grave or tomb. The binder and disintegrant were selected from 7 and 4 candidates, respectively. Kumar r, shirwaikar aa, shirwaikar a, prabhu sl, mahalaxmi r, rajendran k and kumar dc. Preparation and evaluation of solid dispersion tablets by. The choice of a suitable disintegrant and an optimal use level, therefore, are critical to ensure a high disintegration rate.
Heat and certain other physical agents such as live steam can be disinfectants, but in. Synonyms for disintegrate include collapse, fragment, shatter, splinter, crumble, break up, fail, founder, fracture and decline. With nounverb tables for the different cases and tenses links to audio pronunciation and relevant forum discussions free vocabulary trainer. Odt formulations optimal combinations of excipients and. Below this concentration, the tablet disintegration time is inversely proportional to the concentration of the superdisintegrant, whereas if concentration of superdisintegrant is above critical. Starch amylum the mechanism of action of starch is wicking and restoration of deformed starch particles on contact with aqueous fluid and in doing so release of certain amount of stress which is responsible for disruption of hydrogen bonding formed during compression. Roquette has developed a versatile range of standard disintegration excipients. The improved properties of the tablets containing insoluble super disintegrants, when compared to tablets with potato starch, are the result of the use of a much lower concentration of. Cros carmellose sodium, crospovidone, fast disintegrating tablets, prochlorperazine maleate.
To inter a body is to bury it or place it in a mausoleum, so to disinter someone is to take the body out again usually to find out how they died, to make sure its really who we think it is, or to move the body. In other words, the ability for starch to swell is. The dissolution test was conducted using the jp 16 paddle method. English malayalam dictionary malayalam english dictionary english english add on database english add on. Definition of pharmaceutical excipients pharma excipients. Effect of disintegrants on the properties of multiparticulate.
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